[01] Abigail Gbemisola Adeyonu, Department of Agriculture, Landmark University, Omu-Aran, Nigeria. [02] Oghenerobor Benjamin Akpor, Department of Microbiology, Landmark University, Omu-Aran, Nigeria. [03] Olarewaju Michael Oluba, Department of Biochemistry, Landmark University, Omu-Aran, Nigeria. [04] Ayoola John Soyombo, Department of Agriculture, Landmark University, Omu-Aran, Nigeria. [05] Olayinka Olubunmi Alabi, Department of Agriculture, Landmark University, Omu-Aran, Nigeria. [06] Anne Alayemola, Directorate of University Wide Courses, Landmark University, Omu-Aran, Nigeria.

With increase in world population and industrialization coupled with the negative impacts of climate change, the use of agricultural pesticides has increased greatly. The extensive usage of pesticides in farming and residential areas has exposed millions of adults and children all over the world to the detrimental influence of the toxic chemicals. This has resulted into some devastating health challenges lasting the whole of a lifetime of the victims. Children are at a higher risk of exposure than adults. This is due to the fact that the majority of the pesticides usage globally is on fruits and veggies, hence, children are at risk of low-rate but continuous pesticide exposure. This study was therefore aimed at reviewing of the precarious impact of agricultural pesticides on the health of children. The reviews showed that neonatal exposure to agricultural pesticides is responsible for birth defects, cognitive deficits and childhood cancer in children. Also, postnatal exposure to agricultural pesticides has been implicated in children’s respiratory and nervous system diseases. The effect is more on the nervous system. Agricultural pesticides have also been linked to different types of cancer in children. Promotion of integrated farming will be a policy option in other to protect children from hazardous effects of agricultural pesticides.

Agriculture, Pesticides, Health, Body Systems

[01] Food and Agriculture Organization of the United Nations (FAO). The Future of Food and Agriculture: Trends and challenges, FAO, Rome 2017. Available online: www.fao.org/ publications/fofa/en. (accessed on 26 December, 2018). [02] International Labour Organization (ILO). Agriculture; Plantations; Other Rural Sectors, ILO, Geneva 2014. Available online: www.ilo.org/global/industries-and-sectors/agriculture-plantations-other-rural-sectors/lang--en/index.htm. (accessed on 26 December, 2018). [03] International Labour Office 2017. Global Estimates of Child Labour: Results and trends, 2012–2016, International Labour Organization, Geneva 2017. Available online: www.ilo.org/global/topics/child-labour/lang--en/index.htm. (accessed on 30 December, 2018). [04] Lu, C.; Fenske, R. A.; Simcox, N. J.; Kalman, D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environ Res 2000, 84, 290-302. [05] Curl, C. L.; Fenske, R. A.; Kissel, J. C.; Shirai, J. H.; Moate, T. F. et al. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environ Health Perspect 2002, 110, A787-A792. [06] Harnly, M. E.; Bradman, A.; Nishioka, M.; Mckone, T. E. Smith, D.; et al. Pesticides in dust from homes in an agricultural area. Environ Sci Technol. 2009, 43, 8767-8774. [07] Hylanda, C.; Laribib, O. Review of take-home pesticide exposure pathway in children living in agricultural areas. Environmental Research 2017, 156, 559–570. [08] Quandt, S. A., Arcury, T. A.; Rao, P. Snively, B. M.; Camann, D. E.; et al. Agricultural and residential pesticides in wipe samples from farmworker family residences in North Carolina and Virginia. Environ Health Perspect. 2004, 112, 382-387. [09] Arcury, T. A.; Quandt, S. A. (Eds). Latino farmworkers in the Eastern United States: health, safety and justice. New York: Springer 2009, x, 240 p. 13. [10] Bradman, A.; Whitaker, D.; Quirós, L.; Castorina, R. B.; Claus H.; et al. Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA. J Expo Sci Environ Epidemiol 2007, 17, 331-349. [11] Beamer, P. I.; Canales, R. A.; Ferguson, A. C.; Leckie, J. O.; Bradman, A. Relative pesticide and exposure route contribution to aggregate and cumulative dose in young farmworker children. Int J Environ Res Public Health 2012, 9, 73-96. [12] Healthline Media. Worried about pesticide exposure? here’s what you need to know 2019.. Available online: https://www.healthline.com/health-news/pesticide-exposure-heres-what-you-need-to-know#7 (Accessed 27/03/2019). [13] Chalupka, S.; Chalupka, A. N. The impact of environmental and occupational exposures on reproductive health. Journal of Obstetric, Gynecologic, and Neonatal Nursing 2010, 39; 84-100. [14] International Programme on Chemical Safety (IPCS). INCHEM: Chemical safety information from intergovernmental organizations. Geneva 20101, World Health Organization, International Programme on Chemical Safety. [15] Gilden, R. C., Huffling, K.; Sattler, B. Pesticides and health risks. Journal of Obstetric, Gynecologic, and Neonatal Nursing 2010, 39, 103-110. [16] Hu, R.; Huang, X.; Huang, J.; Li, Y.; Zhang, C, Yin, Y.; et al. Long- and Short-Term Health Effects of Pesticide Exposure: A Cohort Study from China. PLoS One 2015, 10, 1-13. [17] Kim, K. H.; Kabir, E.; Jahan, S. A. Exposure to pesticides and the associated human health effects. Science of The Total Environment 2017, 575, 525–535. [18] UNICEF. 2018. Understanding the Impacts of Pesticides on Children: A discussion paper. United Nations Children’s Fund (UNICEF). [19] Beamer, P. I. Pesticide Exposure of Farmworkers’ Children, Pesticides in the Modern World - Effects of Pesticides Exposure, Dr. Margarita Stoytcheva (Ed.), ISBN: 978-953-307-454-2, InTech 2011, Available online: http://www.intechopen.com/books/pesticides-in-the-modern-world-effects-of-pesticidesexposure/. (Accessed 27/01/2019). [20] Pesticide Action Network North America. Kids on the frontline 2016. Available online: https://www.panna.org/sites/default/files/KOF-exsummary-english.pdf (accessed 27/03/2019). [21] WHO. Children are facing high risk from pesticide poisoning. Availkablr at: https://www.who.int/mediacentre/news/notes/2004/np19/en/ (accessed 27/03/2019). [22] Winchester, P. D.; Huskins, J.; Ying, J. Agrichemicals in surface water and birth defects in the United States. Acta Paediatr 2009, 98, 664-669. [23] Marks, A. R.; Harley, K.; Bradman, A.; Kogut, K.; Barr, D. B.; et al. Organophosphate pesticides exposure and attention in young Mexican-American children: the CHAMACOS study. Environ Health Perspect 2010, 118, 1768-1774. [24] Rauh, V.; Arunajadai, S.; Horton, M.; Perera, F.; Hoepner, L.; et al. Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ Health Perspect. 2011, 119, 1196-1201. [25] Grossman, E. Children in Farm Communities Pay Steep Price for the Food We Eat. Available online: https://civileats.com/2016/05/10/ (accessed 27/03/2019). [26] Bouchard, M. F.; Chevrier, J.; Harley, K. G. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environ. Health Perspect. 2011, 119; 1189-1195. [27] Rauh, V. A.; Garcia, W. E.; Whyatt, R. M.; Horton, M. K.; Barr, D. B.; et al. Prenatal exposure to the organophosphate pesticide chlorpyrifos and childhood tremor. Neurotoxicology 2015, 51; 80-86. [28] Shelton, J. F.; Geraghty, E. M.; Tancredi, D. J.; Delwiche, L. D.; Schmidst, R. J.; et al. Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: the CHARGE study. Environ Health Perspect 2014, 122, 1103-1109. [29] González-Alzaga, B.; Hernández, A. F.; Rodríguez-Barranco, M.; Gomez, M. O.; Aquilar-Garduño, M..; et al. Pre- and postnatal exposures to pesticides and neurodevelopmental effects in children living in agricultural communities from South-Eastern Spain. Environment International 2015, 85; 229–237. [30] Raanan, R.; Harley, K. G.; Balmes, J. R.; Brandman, A.; M. Lipsett, M.; et al. Early-life exposure to organophosphate pesticides and pediatric respiratory symptoms in the CHAMACOS cohort. Environ Health Perspect 2015, 123: 179-85. [31] Suhartono, S.; Kartini, A; Subagio, H. W.; Budiyono, Utari, A.; Suratman, S.; Sakundarno, M. Pesticide Exposure and Thyroid Function in Elementary School Children Living in an Agricultural Area, Brebes District, Indonesia. The International Journal of Occupational and Environmental Medicine 2018, 9, 3. [32] Roberts, J. R.; Dawley, D. H.; Reigart, J. R. Children’s low-level pesticide exposure and associations with autism and ADHD: a review. Pediatric Research 2019, 85, 234–241. [33] Lizardi, P. S.; O’Rourke, M. K.; Morris, R. J. The Effects of Organophosphate Pesticide Exposure on Hispanic Children’s Cognitive and Behavioral Functioning. Journal of Pediatric Psychology 2008, 33, 91–101. [34] van Wendel de Joode, B.; Mora, A. M.; Lindh, C. H.; Hernández-Bonilla, D.; Córdoba, L.; et al. Pesticide exposure and neurodevelopment in children aged 6-9 years from Talamanca, Costa Rica. Cortex 2016, 85, 137-150. [35] Carozza, S. E.; Li, B.; Elgethun, K.; Whitworth, R. Risk of childhood cancers associated with residence in agriculturally intense areas in the United States. Environ Health Perspect 2009, 116, 559-565. [36] Yimaer, A.; Chen, G.; Zhang, M.; Zhou, L.; Fang, X.; et al. Childhood pesticide poisoning in Zhejiang, China: a retrospective analysis from 2006 to 2015. BMC Public Health 2017, 17, 602.