American Journal of Food Science and Health
Articles Information
American Journal of Food Science and Health, Vol.3, No.6, Dec. 2017, Pub. Date: Nov. 1, 2017
Palm Wine and Orijin Bitters Severed Hyperlipidemia and Immunomodulatory Responses in Atherogenic-diet Fed Male Wistar Rats
Pages: 106-122 Views: 56 Downloads: 39
Authors
[01] Oyewo Emmanuel Bukoye, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
[02] Adekunle Adeniran Sanmi, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
[03] Afolabi Olusegun Kayode, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
[04] Ige Peace Temidayo, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
[05] Akanji Musbau Adewumi, The Department of Biochemistry, Faculty of Science, Federal University of Technology, Minna, Nigeria.
Abstract
Purpose: This research investigated some health implications of the daily consumption of palm wine and orijin bitters in male Wistar rats fed with atherogenic diet. Materials and Methods: One hundred and fifteen rats were allotted into two groups comprised of 65 and 50 rats, and fed with atherogenic diet (AD) or non-atherogenic diet (N) for six weeks respectively. The rats were administered palm wine and orijin bitters daily, such that: A (AD), B (AD + palm wine), C (AD + orijin bitters), D (AD + simvastatin), E (N), F (N + palm wine), G (N + orijin bitters) for twelve weeks. Results: AD reduced feed intake, which increased after alcoholic beverages were administered (p<0.05). Serum HDL-C and esterified cholesterol were increased (p<0.05) in alcoholic beverages only administered rats, while other lipid parameters were increased (p<0.05) in the AD fed rats. AD and alcoholic beverages increased (p<0.05) total cholesterol and triglycerides in the liver, small intestine and heart. Increases (p<0.05) were obtained in oxLDL-C in the heart and plasma in the AD fed rats, while paraoxonase, glutathione peroxidase and reduced glutathione were reduced (p<0.05). Malondialdehyde was increased (p<0.05) in the liver, heart, small intestine and blood. Increases (p<0.05) were recorded in prealbumin, interleukin-6, TNF-α and C-reactive protein in all the rats, and AD reduced (p<0.05) total immunoglublin and phagocytic capabilities. Conclusions: From the foregoing, it was evident that the administration of the alcoholic beverages severed the hyperlipidemic responses precipitated by the AD and down modulated the immune response. Therefore, the indulgence in alcoholic beverages is highly discouraged with AD.
Keywords
Alcoholic Beverages, Atherogenic Diets, Down Modulated, Hyperlipidemic Responses, Immune Response, Inflammatory Disorders, Severed
References
[01] Adeleke, G. E., Akpabio, C. J., Oyewo, E. B., Maduagwu, E. N. (2015). Acetobacter aceti isolated from fermented palm wine in the southwest region of Nigeria elucidated high nitrosamine production in the presence of nitrite. The J. of Toxicol. and Health. Photon, 106; 494-502.
[02] Adekunle, A. S., Adedeji, A. L., Oyewo, E. B., Adedosu, O. T., Omotoso, A. T. (2013). Hyperlipidemia Induced By Atherogenic Diet Enhanced Oxidative Stress In The Kidney and Inflammatory. Asian journal of natural & applied sciences, 2 (1): 83-93.
[03] Afolabi, O. K., Oyewo, E. B., Adekunle, A. S., Adedosu, O. T., Adedeji, A. L. (2013). Oxidative indices correlate with dyslipidemia and pro-inflammatory cytokine levels in fluoride-exposed rats. Arh High Rads Toksikol. 64 (4):521-9.
[04] Allison, M. F., Lauren, N. B., Reiesha, D. R., Lydia L., Romil S., Naga C. (2011). Effect of different obesogenic diets on pancreatic histology in Ossabaw miniature swine. Pancreas, 40(3), 438-443.
[05] Assadi, F. K. (1989). Acute effect of ethanol on renal electrolyte excretion in rats. Alcohol, 6(3): 257-260.
[06] Anja, S. M., Min, W. S., Kelly, K., Elizabeth, C. L., Renee, E. A. (2004). Hyperlidemia aggravates renal diseases in B6ROP Os/ mice. Kidney Int., 66: 1393-1402.
[07] Assman, G., Gotto, A. (2004). HDL cholesterol and protective factors in atherosclerosis. Circulation, 109 (23 Supply 1): III8-14.
[08] Champe, P., Harvey, R., Ferrier, D. (2005). Lipid metabolism. Lippicott’s illustrated review: Biochemistry. Indian edition, Jaypee Brother Med. Publisher (P) Ltd. Pp. 171-217.
[09] Cordain, L., Byran, E., Melby, C., Smith, M. (1997). influence of moderate daily wine consumption on body weight regulation and metabolism in healthy fre males. J. Am. Coll. Nutr., 16: 134-9.
[10] Eckerson, H. W., Wyte, C. M., La Du, B. N. (1983). The human paraoxanase / acrylesterase polymorphism, Amer. J. Hum. Genet., 35: 1126-38.
[11] Elijah, A. I., Ojimelukwe, P. C., Ekong, U. S., Asamudo, N. U. (2010). Effect of Sacoglottis gabonensis and Alstonia boonei on the kinetics of Saccharomyces cerevisiae isolated from palmwine. Afri. J. of Biotechnol, 9(35); 5730-5734.
[12] Friedewald, W. T., Levy, R. J., Fredriekson, D. S. (1972). Estimating the concentration of low density Lipoprotein Cholesterol in plasma; Clinical chemistry; 18(6):499-562.
[13] Gokhale, A. B., Damre, A. S., Saraf, M. N. (2003). Investigations into immunomodulatory activity of Argyreia speciosa. J Ethnopharmacol 2003; 84:109-14
[14] Goubran, H. A., Kotb, R. R., Stakiw, J., Emara, M. E., Burnouf, T. (2014). Regulation of tumor growth and metastasis: the role of tumor microenvironment. Cancer Growth Metastasis 7, 9-18.
[15] Guder, W. G., Narayanan, S., Wiisser, H., Zawta, B. (1996). List of analytes preanalytical variable. Broschure in: samples: from the patient to the laboratory. Darmstadt: GIT-Verlag.
[16] Harnafi, H., Aziz, M., Amrani, S. (2009). Sweet Basil (Ocimum basilicum L.) improves lipid metabolism in hypercholesterolemic rats. E Spen Eur E J Clin Nutr Metab. 4: e181–6.
[17] Horejsi, L. 2000 Apolipoproteins and atherosclerosis: apolipoprotein E and apolipoprotein(a) as candidate genes of premature atherpsclerosis, Physiol. Res., 49(1): 563-569.
[18] Hu, F. B., Manson, J. E. & Willett, W. C. (2001). Types of dietary fat and risk of coronary heart disease: a critical review. J. Am. Coll. Nutr. 20(1), 5-19.
[19] Kallol, B. D. and Biswadev, B. (2009). Escherichia coli lipopolysaccharide administration alters antioxidant profile during hypercholesterolemia. Ind. J. of Clin. Biochem., 24 (2): 179-183.
[20] Matos, S. L., Paula, H., Pedrosa, M. L., Santos, R. C., Oliveira, E. L., Chianca, Jr. D. A., Silva, M. E. (2005). Dietary models for inducing hypercholesterolemia in rats. Brazilian Archives Biol. Technol., 48(2): 203-209.
[21] Naito, H. K. (1984). Lipids. Clin Chem the C. V. Mosby Co. St Loius. Toronto, Priceton, 1194-11206 and 437.
[22] NIH, 1985. Guide for the Care and Use of Laboratory Animals. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health,. Bethesda, MD., USA., Pp. 83.
[23] Ogbulie, T. E., Ogbulie, J. N., Njoku, H. O. (2007). Comparative study on the microbiology and shelf life stability of palm wine from Elaeis guineensis and Raphia hookeri obtained from Okigwe, Nigeria. African journal of Biotechnology, 6(7), 914-922.
[24] Otunola, G. A, Oloyede, O. B., Oladiji, A. T., Afolayan, A. A. (2010). Effects of diet-induced hypercholesterolemia on the lipid profile and some enzyme activities in female wistar rats African Journal of Biochemistry Research Vol. 4 (6), pp. 149-154.
[25] Oyewo, E. B., Adetutu, A., Adebisi, J. A., Olorunnisola, O. S., Adesokan, A. A. (2013). Sub-chronic administration of Febi super bitters triggered inflammatory responses in male Wistar rats. J. of Med. Sci. (Online).
[26] Pfeiffer, N. E., Mcguire, T. C., Bendel, R. B. (1977). Quantitation of bovine immunoglobulins: comparison of single radial immunodiffusion, zinc sulfate turbidity, serum electrophoresis, and refractometer methods. Am J. Vet. Res., 38: 693-698.
[27] Ramachandran, H. D, Narasimhamurthy, K, Raina, P. L. (2003). Modulation of cholesterol induced hypercholesterolemia through dietary factors in Indian desert gerbils (Meriones hurricinae). Nutr. Res., 23: 245-256.
[28] Reagan-Shaw, S., Nihal, M., Ahmad, N. (2008). Dose translation from animal to human studies revisited. FASEB J; 22:659-61.
[29] Renaud, S., Gueguen, R., Siest, G., Salamon, R. (1999). Wine, beer and mortality in middle-aged men from eastern France. Arch. Intern. Med., 159: 1885-1870.
[30] Sedlak, J., Lindsay, R. H. (1968). Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. 24;25(1):192-205.
[31] Thomas, J. P., Geiger, P. G., Maiorino, M., Ursini, F., Girotti, A. W. (1990). Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artifi- cial bilayers and lipoproteins. Biochim. Biophys. Acta 1045, 252–260.
[32] Tietz, Z., Prude, E. L., Sirgard-Anderson, O. (1995). Tietz textbook of clinical chemistry. 2nd edition, W. B Saunders Company, London, Pp. 1354-1374.
[33] Varshney, R., Kale, R. K. (1990). Effect of calmodulin antagonists on radiation induced lipid peroxidation in microsomes. Int J Radiat Biol., 58:733–743.
[34] Volcik, K. A., Ballantyne, C. M., Fuchs, F. D., Sharrett, A. R. (2008). Relationship of alcohol consumption and type of alcoholic beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC Study. Ann Epidemiol. 18 (2): 101-107.
[35] World Health Organization (WHO 2014), Cardiovascular diseases (CVDs) Fact sheet N°317 March 2013. Retrieved 20 September 2014.
[36] Yeomans, M. R. (2010). Alcohol, appetite and energy balance: is alcohol intake a risk factor for obesity? Physiol. Behav., 100(1); 82-89.
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