American Journal of Food Science and Health
Articles Information
American Journal of Food Science and Health, Vol.1, No.3, Aug. 2015, Pub. Date: Jul. 16, 2015
The HOXD Locus in the Pathogenesis of Celiac Disease
Pages: 82-85 Views: 4187 Downloads: 1057
Authors
[01] Procino Alfredo, Department of Neurosciences, Reproductive and Odontostomatologic Sciences, Medical School Federico II, Naples, Italy.
Abstract
Celiac disease (CD) is immune-mediated enteropathy that occurs in genetically predisposed subjects following ingestion of an alcohol-soluble component of gluten, gliadin, found in some cereals (wheat, barley, rye, spelled, etc.). HOX, are 39 transcription factors mostly involved in the regulation of embryonic development and regulates the cell memory program through the interaction with non coding RNA. I have already titled this network as “The Rosetta stone” of human biology; therefore, does HOX network able to control change in the cell memory program during CD?
Keywords
Celiac Disease, Homeobox, lncRNA, HOTAIR
References
[01] Abadie V, Sollid ML, Barreiro LB and Jabri B. Integration of Genetic and Immunological Insights into a Model of Celiac Disease Pathogenesis Annu. Rev. Immunol. 2011. 29:493– 525.
[02] Iacomino G, Fierro O, D'Auria S, Picariello G, Ferranti P, Liguori C, Addeo F, Mamone G. Structural analysis and Caco-2 cell permeability of the celiac-toxic A-gliadin peptide 31- 55. J Agric Food Chem. 2013 Feb 6;61(5):1088-96.
[03] Troncone R, Auricchio S. Rotavirus and celiac disease: clues to the pathogenesis and perspectives on prevention. J Pediatr Gastroenterol Nutr. 2007;44:527-8.
[04] Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, et al. 2010. Multiple common variants for celiac disease influencing immune gene expression. Nat. Genet. 42:295–302.
[05] Ferber S, Halkin A, Cohen H, Ber I, Einav Y, et al. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6: 568-572.
[06] Foucher I, Volovitch M, Frain M, Kim JJ, SouberbielleJC, et al. (2002) Hoxa5 overexpression correlates with IGFBP1upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors. Development 129: 4065-4074.
[07] Barnes TM, Kohara Y, Coulson A, Hekimi S (1995) Meiotic recombination, noncoding DNA and genomic organization in Caenorhabditiselegans. Genetics 141: 159-179.
[08] Bantignies F, Cavalli G (2006) Cellular memory and dynamic regulation of polycomb group proteins. Curr Opin Cell Biol 18: 275-283.
[09] Gehring W.J., Hiromi Y (1986) Homeotic genes and the homeobox. Annu Rev Genet 20: 147-173.
[10] Functional demarcation of active and silent chromatin domains in human hox loci by noncoding RNAs. 2007. Rinn, J.L.; Kertesz, M.; Wang, J.K.; Squazzo, S.L.; Xu, X.; Brugmann, S.A.; Goodnough, L.H.; Helms, J.A.; Farnham, P.J.; Segal, E.; et al. Cell 129, 1311–1323.
[11] Long noncoding rnahotair regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. 2011. Kogo, R.; Shimamura, T.; Mimori, K.; Kawahara, K.; Imoto, S.; Sudo, T.; Tanaka, F.; Shibata, K.; Suzuki, A.; Komune, S. Cancer Res. 71, 6320–6326.
[12] Long non-coding RNAs in cancer progression. Tano, K.; Akimitsu, N. 2012 Front. Genet.3, 219.
[13] The sequence, structure and evolutionary features of hotairin mammals. He, S.; Liu, S.; Zhu, H. 2011 BMC Evolut. Biol.11, 102.
[14] Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients. Juuti-Uusitalo K, Maki M, Kainulainen H, Isola J, Kaukinen K 2007 Clin ExpImmunol 150: 294–305.
[15] The lincRNA Hotair is required for epithelial-to-mesenchymal transition and stemness maintenance of cancer cell lines. Pádua Alves C1, Fonseca AS, Muys BR, de Barros E Lima Bueno R, Bürger MC, de Souza JE, Valente V, Zago MA, Silva WA Jr. Stem Cells. 2013 Dec; 31(12): 2827-32.
[16] Long non-coding RNA HOTAIR is a powerfu predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer.Wu ZH, Wang XL, Tang HM, Jiang T, Chen J, Lu S, Qiu GQ, Peng ZH, Yan DW. Oncol Rep. 2014 Jul; 32(1):395-402.
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