International Journal of Animal Biology
Articles Information
International Journal of Animal Biology, Vol.2, No.1, Feb. 2016, Pub. Date: Feb. 17, 2016
Antioxidants and Hypoglycemic Studies on Egyptian Propolis and Foeniculum Vulgare on Alloxan Induced Diabetic Rats
Pages: 1-10 Views: 1267 Downloads: 1156
Authors
[01] Samir A. M. Zaahkouk, Department of Zoology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
[02] Diaa F. Ibrahim, Department of Zoology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
[03] Bassem E. Elarabi, Department of Zoology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Abstract
Background: Diabetes Mellitus (DM) is one of the leading causes of death, illness, and economic loss in the Egypt. In DM the oxidative stress exceeds the body’s antioxidant defense mechanisms. Although oxidative stress and free radicals have been reported to play a significant role in diabetic complications. Propolis and Foeniculum vulgare (fennel) possesses antioxidant and anti-diabetic activities. Aim of work: This study was carried out to evaluate the effect of Egyptian propolis and Foeniculum Vulgare on hyperglycemia-induced oxidative stress in diabetic rats. Materials and methods: Diabetes was induced with Alloxan (148mg/Kg) intraperitoneal. Rats with blood glucose level less than 300 mg/dL were excluded. Animals were divided into 8 equal groups (n=80); except negative control rats, all groups inoculated with alloxan Group 1: negative control of normal rats. Group 2: positive control of alloxan injected rats. Group 3: rats were treated with 200 mg/ kg of propolis. Group 4: rats were treated with 400 mg/ kg of propolis. Group 5: rats were treated with 200 mg/ kg of Foeniculum vulgare. Group 6: rats were treated with 400 mg/ kg of Foeniculum vulgare. Group 7: rats were treated with (200 mg/ kg of Foeniculum vulgare +200 mg/ kg of propolis). Group 8: rats were treated with (400 mg/ kg of Foeniculum vulgare +400 mg/ kg of propolis). Rats were treated orally for 28 days. Results: Data showed significant increase in serum levels of Fasting blood glucose FBG, malonaldehyde MDA, superoxide dismutase SOD and significant decreased levels of insulin, Catalase, glutathione (GSH) reduce, glutathione -S- transferase (GST) were observed in the diabetic untreated animals. Conclusion: Propolis and Foeniculum Vulgare possesses hypoglycemic activities in addition to its ability to ameliorate oxidative stress induced organ dysfunction.
Keywords
Diabetes, Propolis, Foeniculum Vulgare, Alloxan, Hyperglycemia, Oxidative Stress
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