International Journal of Bioinformatics and Biomedical Engineering
Articles Information
International Journal of Bioinformatics and Biomedical Engineering, Vol.4, No.4, Dec. 2018, Pub. Date: 16, 2019
Evaluation of Renal Diseases Risk Factors Among Hypertensive Patients in Zawia Region, Western Libya
Pages: 70-75 Views: 999 Downloads: 381
[01] Ashraf Mohamed Albakoush, Department of Medical Laboratory, Faculty of Medical Technology, Sabratha University, Surman, Libya.
[02] Azab Elsayed Azab, Department of Physiology, Faculty of Medicine, Sabratha University, Sabratha, Libya.
[03] Jbireal Masoud Jbireal, Department of Physiology, Faculty of Medicine, Sabratha University, Sabratha, Libya.
[04] Abdulnaser Elshibani Mohammed Elharabi, National Centre for Diseases Control, Faulty of Medicine, Tripoli University, Sabratha, Libya.
[05] Khalid Saied Osman Elnour, Department of Medical Laboratory, Faculty of Medical Technology, Zawia University, Zawia, Libya.
The aim of the study: This study was conducted to evaluate renal function in hypertensive patients using the estimated Glomerular Filtration Rate (eGFR). Methods: This study was conducted during August 2018, the subjects enrolled in this study divided into two groups (study group, control group). Study group, consists of 44 hypertensive patients (HTN). Control group was consists of 50 apparently healthy volunteers. A complete data record was obtained including name, age, gender, duration of hypertension, blood pressure (BP), weight, and height using standardized questionnaire. Members of both groups were within the same social class and dietary habit. Blood sample were obtained from both groups for measurement of creatinine, and urea. Venous blood was drawn in plain blood tube containing clot activator and immediately centrifuged at 3000 rpm for 5 minutes to obtain serum and immediately analyzed. The eGFR calculated using a software depend on the Modification of Diet in Renal Disease (MDRD) Study equation. Results: The present study showed that a significant increased in serum urea and creatinine levels in hypertensive patients when compared with healthy volunteers. On the other hand, the eGFR was significantly decreased in hypertensive patients as compared to healthy subjects. 31.8% of patients were in stage one, 40.9% in stage 2, and 15.9% in stage 3A, 4.5% in stage 3 B, and 6.8% in stage 5. The eGFR was decreased significantly with increasing of BMI and duration of hypertension. No correlation was observed between GFR and age, gender, and blood pressure. Conclusion: This study concluded that serum urea and creatinine were a significant increased and eGFR was significantly decreased and correlated with hypertension duration in hypertension patients. In some forms of CKD, HTN may be the earliest sign of kidney dysfunction and appropriate HTN management reduces kidney outcomes. Therefore, the hypertensive patient’s should be advised to check the kidney functions periodically to avoid renal failure.
Chronic Renal Failure, eGFR, Hypertension, Kidney Function
[01] Heins Valtin, James A Schafer. Renal function. 3rd edition. New York: Little Brown and Company; 1995.
[02] National Kidney Foundation. KDOQI Clinical Practice Gbrontc Kidney Disease; Evaluation, Classification and Stratification. Am J Kidney Dis. 2002; 39: S1-S266.
[03] Mascha V, Rashmi K, Priyadarshi SS, et al. Comparing age wise reference intervals for serum creatinine concentration in a “reality check” of the recommended cut-off. Indian J ClinBiochem. 2006; 21:90-94.
[04] Eduardo OC, Kaue A, Idania AA, et al. Influence of hemodialysis on the plasma concentration of adenosine deaminase in patients with chronic kidney disease. J Bras Patol Med Lab. 2015; 51:153-157.
[05] Al-Hisnawi RA, Salih H. A study of some biochemical changes in patients with chronic renal failure undergoing hemodialysis Int. J. Curr. Microbiol. App. Sci. 2014; 3(5): 581-586.
[06] Noor ul A, Raja Tahir M, JavaidAsad M, et al. evaluating urea and creatinine levels in chronic renal failure pre and post dialysis: A prospective study. J Cardiovasc Disease. 2014; 2: 1-5.
[07] Azra K. Estimation of blood urea (BUN) and serum creatinine level in patients of renal disorder. J Fundam Appl Sci. 2014; 4:199-202.
[08] Manrique C, Lastra G, Gardner M, Sowers JR. The renin angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress. Med Clin North Am. 2009; 93:569-582.
[09] Allhat Collaborative Research Group: Major Outcomes in high-risk hypertensive patients randomized to angiotensin converting enzyme inhibit or calcium channel blocker vs. diuretic: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA 2002; 288: 2981.
[10] Rakhee Yadav, Jai Prakash Bhartiya, Sunil Kumar Verma, Manoj Kumar Nandkeoliar. Evaluation of blood urea, creatinine and uric acid as markers of kidney functions in hypertensive patients: a prospective study. Indian J Basic Appl Med Res. 2014; 3(2): 682-689.
[11] Mathisen, U, Melsom, T, Ingebretsen, OC, Jenssen, TG, Njølstad, I, Solbu, MD, Toft, I, Eriksen, BO. The relationship between glomerular filtration rate measured as iohexol-clearance and ambulatory blood pressure in the general population: Pp.9.364. J Hypertension 2010; 28: e159 doi: 10.1097/
[12] Garofalo C, Borrelli S, Pacilio M, Minutolo R, Chiodini P, De Nicola L, Conte G. Hypertension and prehypertension and prediction of development of decreased estimated GFR in the general population: a meta-analysis of cohort studies. American Journal of Kidney Diseases. 2016; 67(1): 89-97. DOI:
[13] Leoncini G, Sacchi G et al. Microalbuminuria is an integrated marker of subclinical organ damage in primary hypertension. J hypertension 2002; 16: 399.
[14] Zheng D, Sato S, Arima H, Heeley E, Delcourt C, Cao Y, Chalmers J, Anderson CS, Anderson CS, Chalmers J, Arima H. Estimated GFR and the effect of intensive blood pressure lowering after acute intracerebral hemorrhage. Amer J Kidney Diseases. 2016; 68(1): 94-102.
[15] Christian Nordqvist, CarissaStephen, RN, CCRN, CPN. Symtoms, causes, and treatment of chronic kidney disease. Med News today: 2017 Dec 13.
[16] Bjorn O. Eriksen, Vidar T. N. Stefansson, Trond G. Jenssen, Ulla D. Mathisen, Jørgen Schei, Marit D. Solbu, Tom Wilsgaard, and Toralf Melsom. Blood pressure and age-related GFR decline in the general population. BMC Nephrol. 2017; 18: 77. doi: 10.1186/s12882-017-0496-7.
[17] Duzova A, Yalçinkaya F, Baskin E, Bakkaloglu A, Soylemezoglu O. Prevalence of hypertension and decreased glomerular filtration rate in obese children: results of a population-based field study. Nephrol Dial Transplant. 2013; Suppl 4:iv166-171. doi: 10.1093/ndt/gft317.
[18] Sacks FM, Campos H. Dietary therapy in hypertension. N Engl J Med. 2010; 362: 2102-2112.
MA 02210, USA
AIS is an academia-oriented and non-commercial institute aiming at providing users with a way to quickly and easily get the academic and scientific information.
Copyright © 2014 - American Institute of Science except certain content provided by third parties.