International Journal of Bioinformatics and Biomedical Engineering
Articles Information
International Journal of Bioinformatics and Biomedical Engineering, Vol.4, No.4, Dec. 2018, Pub. Date: 16, 2019
Evaluation of Renal Diseases Risk Factors Among Hypertensive Patients in Zawia Region, Western Libya
Pages: 70-75 Views: 394 Downloads: 196
Authors
[01] Ashraf Mohamed Albakoush, Department of Medical Laboratory, Faculty of Medical Technology, Sabratha University, Surman, Libya.
[02] Azab Elsayed Azab, Department of Physiology, Faculty of Medicine, Sabratha University, Sabratha, Libya.
[03] Jbireal Masoud Jbireal, Department of Physiology, Faculty of Medicine, Sabratha University, Sabratha, Libya.
[04] Abdulnaser Elshibani Mohammed Elharabi, National Centre for Diseases Control, Faulty of Medicine, Tripoli University, Sabratha, Libya.
[05] Khalid Saied Osman Elnour, Department of Medical Laboratory, Faculty of Medical Technology, Zawia University, Zawia, Libya.
Abstract
The aim of the study: This study was conducted to evaluate renal function in hypertensive patients using the estimated Glomerular Filtration Rate (eGFR). Methods: This study was conducted during August 2018, the subjects enrolled in this study divided into two groups (study group, control group). Study group, consists of 44 hypertensive patients (HTN). Control group was consists of 50 apparently healthy volunteers. A complete data record was obtained including name, age, gender, duration of hypertension, blood pressure (BP), weight, and height using standardized questionnaire. Members of both groups were within the same social class and dietary habit. Blood sample were obtained from both groups for measurement of creatinine, and urea. Venous blood was drawn in plain blood tube containing clot activator and immediately centrifuged at 3000 rpm for 5 minutes to obtain serum and immediately analyzed. The eGFR calculated using a software depend on the Modification of Diet in Renal Disease (MDRD) Study equation. Results: The present study showed that a significant increased in serum urea and creatinine levels in hypertensive patients when compared with healthy volunteers. On the other hand, the eGFR was significantly decreased in hypertensive patients as compared to healthy subjects. 31.8% of patients were in stage one, 40.9% in stage 2, and 15.9% in stage 3A, 4.5% in stage 3 B, and 6.8% in stage 5. The eGFR was decreased significantly with increasing of BMI and duration of hypertension. No correlation was observed between GFR and age, gender, and blood pressure. Conclusion: This study concluded that serum urea and creatinine were a significant increased and eGFR was significantly decreased and correlated with hypertension duration in hypertension patients. In some forms of CKD, HTN may be the earliest sign of kidney dysfunction and appropriate HTN management reduces kidney outcomes. Therefore, the hypertensive patient’s should be advised to check the kidney functions periodically to avoid renal failure.
Keywords
Chronic Renal Failure, eGFR, Hypertension, Kidney Function
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