International Journal of Biomedical and Clinical Sciences
Articles Information
International Journal of Biomedical and Clinical Sciences, Vol.2, No.3, Aug. 2017, Pub. Date: Dec. 21, 2017
Clinical Profile and Management Modalities of Vitamin D Deficiency and Insufficiency Among Adult’s Cohorts at Primary Health Care Facilities
Pages: 22-25 Views: 269 Downloads: 91
Authors
[01] Hamid Yahya Husain, Primary Health Care/ Dubai Health Authority, Dubai, UAE.
[02] Zekeria Kareem, Primary Health Care/ Dubai Health Authority, Dubai, UAE.
[03] Kadhim Al Abbady, Primary Health Care/ Dubai Health Authority, Dubai, UAE.
Abstract
This study is aiming assess the prevalence of Vit D Insufficiency and Deficiency among Adult cohort in Dubai, To study the epidemiological profile and associated factors, study methodology was a cross sectional study carried out on ( 80 ) Adult patient, age rage( 15-70 y ) randomly selected from Vitamin deficiency and insufficiency cohorts registered and attending primary health care facilities at Dubai health authority, full social- demographic and clinical data has been collected through data collection interview questionnaire, patients follow up has been extended for up to one year in relation to lab investigation follow up, vitamin D therapy, health education, life style intervention and physical examination ( operational definitions of variables, inclusion-exclusion criteria, scale of measurement and ethical considerations has been addressed properly throughout the research course. The result showed by the study revealed that 8.75% of Vitamin D Deficiency and 2.5% of vitamin D insufficiency cohort shown an association with chronic illness, 37.75% deficiency and 13.75% insufficiency showed associated with the cohort life style (lack of Direct Exposure to sun), 35% of Vitamin deficiency and 15% with vitamin insufficiency showed association with quality of dietary intake. The study revealed that 5% of the adults with vitamin deficiency where having hypertension, 2.5% diabetes, 2.5% dyslipidemia, 2.5% hypothyroidism ad 2.5% with asthma, while Vitamin D insufficiency associated with hypertension 8.75%, diabetes 5%, dyslipidemia 6.25%, hypothyroidism 5% and asthma 3.75%). About 30% of total abnormal serum vitamin D were deficiency <10 and 70% were shown insufficiency 10-30 32.5% of abnormal serum vitamin D were male and 67.5% were females. vitamin D deficiency and insufficiency studied sample about 30% given Vitamin D supplement 5000 IU week for three month cycle to be re evaluated again and 70% were given 100 IU vitamin D supplement daily for three month cycle to be re evaluated again by serum vitamin D level). The study reflect that in the clinical assessment and follow up protocol applied about 30% of the total sample were investigated with serum calcium, yet 70% serum calcium were not carried out for them and only 27.5% of the total number of patient enrolled in the study were followed up with repeated serum vitamin d after each treatment cycle, while 74.5% were not considered for serum vitamin d monitoring.
Keywords
Clinical, Management, Vitamin D, PHC
References
[01] Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. Journal of Bone and Mineral Research. 2000; 15(6):1113–1118. [PubMed].
[02] Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporosis International. 2009;20(2):315–322. [PubMed].
[03] Lips P. Interaction between vitamin D and calcium. Scandinavian Journal of Clinical and Laboratory Investigation, Supplementum. 2012; 243:60–64. [PubMed].
[04] Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Archives of Internal Medicine. 2009; 169(6):551–561. [PubMed].
[05] Khosla S. What do we tell our patients about calcium and vitamin D supplementation? Journal of Clinical Endocrinology and Metabolism. 2011; 96(1):69–71. [PubMed].
[06] Milazzo L, Mazzali C, Bestetti G, et al. Liver-related factors associated with low vitamin D levels in HIV and HIV/HCV coinfected patients and comparison to general population. Current HIV Research. 2011;9(3):186–193. [PubMed.
[07] Tom D. Thacher, MD and Bart L. Clarke, MD, Vitamin D Insufficiency, Mayo Clin Proc. 2011 Jan; 86(1): 50–60. doi: 10.4065/mcp.2010.0567PMCID: PMC3012634.
[08] Zamora SA, Rizzoli R, Belli DC, Slosman DO, Bonjour JP. Vitamin D supplementation during infancy is associated with higher bone mineral mass in prepubertal girls. J Clin Endocrinol Metab. 1999;84(12):4541-4544 [PubMed].
[09] Cranney A, Horsley T, O'Donnell S, et al. Effectiveness and safety of vitamin D in relation to bone health. Evidence Report/Technology Assessment No 158 Published August 2007. AHRQ Publication No 07-E013 Rockville, MD: Agency for Healthcare Research and Quality; http://www.ahrq.gov/downloads/pub/evidence/pdf/vitamind/vitad.pdf Accessed November 8, 2010.
[10] nonskeletal effects of vitamin D has been increasing since the discovery of vitamin D receptors and the 1α-hydroxylase enzyme in multiple tissues, including cells of the pancreas, immune system, macrophages, vascular endothelium, stomach, epidermis, colon, and placenta.
[11] 40. Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, et al. Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res. 2009;24(5):935-942 [PMC free article] [PubMed].
[12] Ginde AA, Scragg R, Schwartz RS, Camargo CA., Jr Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults. J Am Geriatr Soc. 2009;57(9):1595-1603 [PubMed].
[13] Pittas AG, Dawson-Hughes B, Li T, et al. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006;29(3):650-656 [PubMed].
[14] Litonjua AA. Childhood asthma may be a consequence of vitamin D deficiency. Curr Opin Allergy Clin Immunol. 2009;9(3):202-207 [PMC free article] [PubMed].
[15] Wjst M, Dold S. Genes, factor X, and allergens: what causes allergic diseases? Allergy. 1999; 54(7):757-759 [PubMed].
[16] Brehm JM, Celedon JC, Soto-Quiros ME, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med. 2009;179(9):765-771 [PMC free article] [PubMed].
[17] Fulgoni V. L., III, Keast D. R., Bailey R. L., Dwyer J. Foods, fortificants, and supplements: Where do Americans get their nutrients? J. Nutr. 2011;141:1847–1854. doi: 10.3945/jn.111.142257. [PMC free article] [PubMed] [Cross Ref].
[18] Langlois K., Greene-Finestone L., Little J., Hidiroglou N., Whiting S. Vitamin D status of Canadians as measured in the 2007 to 2009 Canadian Health Measures Survey. Health Rep. 2010;21:47–55. [PubMed].
[19] Wang T. J., Pencina M. J., Booth S. L., Jacques P. F., Ingelsson E., Lanier K., Benjamin E. J., D’Agostino R. B., Wolf M., Vasan R. S. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503–511. doi: 10.1161/CIRCULATIONAHA.107.706127. [PMC free article] [PubMed] [Cross Ref].
[20] Ginde A. A., Scragg R., Schwartz R. S., Camargo C. A., Jr. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U. S. adults. J. Am. Geriatr. Soc. 2009;57:1595–1603. doi: 10.1111/j.1532-5415.2009.02359.x. [PubMed] [Cross Ref].
[21] Rostand S. G. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 1997; 30:150–156. doi: 10.1161/01.HYP.30.2.150. [PubMed] [Cross Ref].
[22] Martins D., Wolf M., Pan D., Zadshir A., Tareen N., Thadhani R., Felsenfeld A., Levine B., Mehrotra R., Norris K. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: Data from the Third National Health and Nutrition Examination Survey. Arch. Intern. Med. 2007;167:1159–1165. doi: 10.1001/archinte.167.11.1159. [PubMed] [Cross Ref].
[23] Brewer L. C., Michos E. D., Reis J. P. Vitamin D in atherosclerosis, vascular disease, and endothelial function. Curr. Drug Targets. 2011;12:54–60. doi: 10.2174/138945011793591617. [PubMed] [Cross Ref].
[24] Modan M., Halkin H., Almog S., Lusky A., Eshkol A., Shefi M., Shitrit A., Fuchs Z. Hyperinsulinemia. A link between hypertension obesity and glucose intolerance. J. Clin. Investig. 1985;75:809–817. doi: 10.1172/JCI111776. [PMC free article] [PubMed] [Cross Ref].
[25] Dankner R., Chetrit A., Shanik M. H., Raz I., Roth J. Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: A preliminary report. Diabetes Care. 2009;32:1464–1466. doi: 10.2337/dc09-0153. [PMC free article] [PubMed] [Cross Ref].
[26] Pittas A. G., Lau J., Hu F. B., Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 2007;92:2017–2029. doi: 10.1210/jc.2007-0298. [PMC free article] [PubMed] [Cross Ref].
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