[01] Jalal Hasan Mohammed, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Karbala, Karbala, Iraq.

In this study the chemistry of chalcones has generated intensive scientific interest due to their biological and industrial applications. Chalcones are natural biocides and are well known intermediates in the synthesis of heterocyclic compounds exhibiting various biological activities. Chalcones and their derivatives possess some interesting biological properties such as antibacterial, antifungal, insecticidal, anesthetic, antiinflammatory, analgesic etc. Different methods are available for the preparation of chalcones. The most convenient method is the Claisen-Schimdt condensation of equimolar quantities of arylmethylketone with aryl aldehyde in the presence of alcoholic alkali, In the Claisen-Schmidt reaction, the concentration of alkali used, usually ranges between 10 and 60 %. The reaction is carried out at about 50 C for 12-15 hours or at room temperature for one week.

Chalcones, Antibacterial, Antifungal, Anti-Inflammatory

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