[01] Husni Abdulla Mhammad, Faculty of Science, University of Duhok, Duhok, Iraq. [02] Amad M. Saleh Jubrail, Faculty of Science, University of Duhok, Duhok, Iraq. [03] Malika Kassim Najeeb, Faculty of Science, University of Duhok, Duhok, Iraq.

The present study was designed to investigate the effects of impact of cinnamon extract on some physiological, biochemical, hematological parameters among normal, hyperlipidemic and diabetic rats. Seventy adult male rats were randomly divided into seven groups each with 10 rats; each group was designed as follows: The first group was used as a control and was fed on standard diet and tap water ad libitum. The second group was treated with alcoholic cinnamon extract (500 mg/kg.bw). Third group was fed on high cholesterol diet (hyperlipidemic) while the fourth group was fed on high cholesterol diet and treated with alcoholic cinnamon extract (500 mg/kg.bw). The fifth group was injected with alloxan as a diabetic group. The sixth group was diabetic rats treated with alcoholic cinnamon extract (500 mg/kg.bw) and the seventh group; diabetic rats were treated with metformin drug (300 mg/kg.bw). After 30 days of experiment, rats were anaesthetized and the blood was taken by cardiac puncture for estimation of hematological, biochemical and immunological parameters. From the obtained results, the mean value of fasting blood glucose level in hyperlipidemic rats (135.5±1.9mg/dl) and diabetic rats (401.8±3.5 mg/dl) was significantly decreased when hyperlipidemic rats (123.2±1.9 mg/dl) and diabetic rats (221.1±3.5 mg/dl) treated with cinnamon extract and further decreased when diabetic rats treated with metformin drug (161.56±2.2 mg/dl) in comparison with control group (107.2±2.7 mg/dl). The mean values for serum lipid in hyperlipidemic rats were significantly decreased when hyperlipidemic rats treated with cinnamon extract as follows: total cholesterol (120.7±1.9 to 95.10±2.2 mg/dl), triglyceride (138.8±3.1to 102.8±1.51mg/dl), low-density lipoprotein (LDL) (56.24±1.9 to 33.14±1.9mg/dl) and very low-density lipoprotein (VLDL) (27.76± 0.62 to 20.56± 0.30 mg/dl). In diabetic rats, total cholesterol, triglyceride, LDL, and VLDL were significantly decreased when treated with cinnamon extract and metformin drug. The level of high-density lipoprotein (HDL) was improved when hyperlipidemic and diabetic rats treated with cinnamon extract. In diabetic rats, red blood cells, hemoglobin, packed cell volume, platelets were lower, but after treating of cinnamon extract; these parameters improved to significant level in diabetic rats. Conclusion: From the results of the present study, it can be concluded that extract of cassia cinnamon bark is effective in controlling blood glucose level, serum lipids among hyperlipidemic and diabetic rats.

Cinnamon Extract, Hyperlipidemic Rats, Diabetic Rats, Metformin Drug

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