International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.1, No.4, Dec. 2015, Pub. Date: Sep. 18, 2015
Behaviour of Metals and Thyroid Hormones in Hyperthyroid Patients
Pages: 227-237 Views: 2415 Downloads: 1004
Authors
[01] Saadia R. Tariq, Department of Chemistry, Lahore College for Women University, Lahore, Pakistan.
[02] Asma Rashid Tariq, Institute of Chemistry, the University of Punjab, Lahore, Pakistan.
[03] Samra Lateef, Department of Chemistry, Lahore College for Women University, Lahore, Pakistan.
[04] Farhana Mazhar, Department of Chemistry, Lahore College for Women University, Lahore, Pakistan.
Abstract
Trace metals are known to trigger many biological reactions. Any imbalance in their levels may cause various thyroid disorders like hyperthyroidism. It is therefore, quite important to study the relationships between trace metals and thyroid hormones to help understand the etiology of disease and search for an appropriate treatment regime. To this effect, the levels of selected trace metals were determined in fifty one patients of hyperthyroidism and their age and gender matched healthy controls by using flame atomic absorption spectrophotometer following wet digestion method and the levels of free T3, T4 and TSH were determined by radioimmunoassay technique available at the laboratories of Jinnah Hospital, Lahore. The study evidenced that all the selected trace metals (Cr, Co, Cd, Fe, Ni) were present at enhanced levels in the blood of patients as compared to healthy controls. These metals may affect the thyroid functions (like conversion of T4 to T3) by disturbing the activity of thyroid peroxidase like enzymes. An increasing trend in the concentration of all the metals except Ni was observed with age. Correlation study evidenced Co to be significantly positively correlated with TSH. Gender based studies revealed higher mean values of metals in male patients than in female patients. The exposure of individuals to various metals may lead to the enhanced levels of these metals in the blood. These metals being catalysts for many biological reactions may cause imbalance in thyroid hormones, leading to thyroid dysfunction.
Keywords
Hyperthyroidism, Metals, T4, Thyroid Stimulating Hormone, Triiodothyronine
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