International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.1, No.4, Dec. 2015, Pub. Date: Nov. 12, 2015
Influence of IgG Separated from Blood Plasma of Patients with Ischemic Stroke on the Process Platelet's Proteins Secretion
Pages: 278-283 Views: 1162 Downloads: 903
Authors
[01] Katrii T. B., Department of Biochemistry, Educational and Scientific Centre "Institute of Biology", Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
[02] Vovk T. B., Department of Biochemistry, Educational and Scientific Centre "Institute of Biology", Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
[03] Kravchenko N. K., Department of Biochemistry, Educational and Scientific Centre "Institute of Biology", Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
[04] Savchuk O. M., Department of Biochemistry, Educational and Scientific Centre "Institute of Biology", Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
[05] Ostapchenko L. I., Department of Biochemistry, Educational and Scientific Centre "Institute of Biology", Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
Abstract
Influence of IgG accumulated in the blood plasma of patients with different types of ischemic stroke (atherothrombotic and cardioembolic) and with another neurological diseases (without stroke in anamneses) on the platelets was investigated. Influence of thrombin and collagen was tested too. Presence in the medium of incubation of most common proteins like Plasminogen activator inhibitor (PAI-1), von Willebrand factor (vWF), Heat shock proteins (Hsp-60, Hsp-70) were detected through the Western blot method.
Keywords
IgG, PAI-1, FvW, Hsp-60, HsP-70, Ischemic Stroke
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