International Journal of Chemical and Biomolecular Science
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International Journal of Chemical and Biomolecular Science, Vol.2, No.1, Feb. 2016, Pub. Date: Jan. 6, 2016
Synthesis and Antimicrobial Activity of Some Substituted Cyclopentyl Phenols
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[01] D. A. Pisanenko, Chemical Technologies of Organic Substances, National Technical University of Ukraine "Kyiv Polytechnic Institute", Kiev, Ukraine.
[02] Yu. L. Voljanskii, Mechnikov Institute of Microbiology and Immunology, Academy of Medical Sciences of Ukraine, Charkov, Ukraine.
Some substituted cyclopentyl phenols were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Streptococcus viridans, Escherichia coli, Shigella flexneri, Salmonella typhi, Salmonella typhimurium, B.proteus vulgaris, Pseudomonas aeruginosa, Bacterium antracoides, Bacterium subtilis, Klebsiella rhinoscleuromatis and Candida albicans using the microdilution method. Antimicrobial tests results indicated that all compounds have reasonable activity. They displayed the highest antimicrobial activity against Streptococcus aureus and Streptococcus viridans. The cyclopentyl phenols containing aryl substituted cyclopentyl radicals were the most active in the series against all tested bacteria and fungi strains.
Substituted Cyclopentyl Phenols, Synthesis, Antibacterial Activity, Antifungal Activity
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