International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.2, No.3, Jun. 2016, Pub. Date: May 12, 2016
Study the Effect of Some New Synthesis Cysteine Complex on Clinical Bacterial and Fungal Isolates
Pages: 56-59 Views: 1425 Downloads: 836
Authors
[01] Veyan Taher Seleman, Chemistry Department, Faculty of Science, University of Duhok, Duhok, Iraq.
[02] Vian Yamin Jarjes, Chemistry Department, Faculty of Science, University of Duhok, Duhok, Iraq.
[03] Marwan Khalil Qader, Biology Department, Faculty of Science, University of Duhok, Duhok, Iraq.
Abstract
Synthesis, characterization, and biological activity of a new (cysteine) complexes, the complex are consistent with the formula [M2ClSn (C6H12N2O4S2)2]. The IR spectroscopy show coordination of the ligand to M(II) through four N atoms in a square planar geometry. The dinuclear complexes of Mn+2 Co+2, Ni+2, Cu+2 and Zn+2 were prepared by the reaction of the above ligands with the metal chloride in (1:2) metal to ligands ratio. The ligands and their complexes have been characterized by their analytical, spectral data, conductivity and magnetic measurements. Electronic spectra and magnetic measurements indicates that the dinuclear have square planar geometry. Final solutions of the complex against Bacterial and Fungicides showed a pronounced activity of the complex even at low concentrations at 10-3 m in ethanol solvent. The antibacterial activities of synthesized compounds were studied against Gram-negative pathogen bacterial species (Gram-negative species Pseudomonas areugenosa, Escherichia coli and Klebsiella pneumonia. Gram positive species Staphylococcus aureus and Streptococcus pyogenes. The antifungal activity of synthesized compounds were studied against some species of Candida C. tropicalis, C. albicanus, C. dublicans, C. krusei and C. glabrata using the disc diffusion method. The results showed that all complexes exhibited prominent antimicrobial activity against the tested isolates measuring inhibition zones at several values in mm.
Keywords
Cysteine, Ligands, Antifungal, Antibacterial
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