International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.4, No.1, Mar. 2018, Pub. Date: May 24, 2018
Synthesis and Inspection of Some Novel Quinazolinone Derivatives as Antimicrobial Agents
Pages: 1-8 Views: 637 Downloads: 328
Authors
[01] Manal Mohamed El-Shahawi, Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
[02] Maher A. El-Hashash, Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
[03] Eman Ali Ragab, Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
[04] Sanaa Nagdy, Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Abstract
Treatment of 2-amino-6-iodoquinazolin-4(3H)-one with ethyl chloroacetate in the presence of potassium carbonate in dry acetone, followed by hydrazinolysis of the product afforded the corresponding acid hydrazide. The reactivity of acid hydrazide towards different carbon electrophiles has been investigated. Antimicrobial activity of some synthesized compounds has been evaluated and most of them give moderate activity.
Keywords
Quinazolinones, Acid Hydrazide, 1,2,4-Triazoles, 1,3,4-Oxadiazoles, Antimicrobial Activity
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