International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.4, No.1, Mar. 2018, Pub. Date: May 24, 2018
Synthesis and Inspection of Some Novel Quinazolinone Derivatives as Antimicrobial Agents
Pages: 1-8 Views: 637 Downloads: 328
[01] Manal Mohamed El-Shahawi, Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
[02] Maher A. El-Hashash, Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
[03] Eman Ali Ragab, Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
[04] Sanaa Nagdy, Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Treatment of 2-amino-6-iodoquinazolin-4(3H)-one with ethyl chloroacetate in the presence of potassium carbonate in dry acetone, followed by hydrazinolysis of the product afforded the corresponding acid hydrazide. The reactivity of acid hydrazide towards different carbon electrophiles has been investigated. Antimicrobial activity of some synthesized compounds has been evaluated and most of them give moderate activity.
Quinazolinones, Acid Hydrazide, 1,2,4-Triazoles, 1,3,4-Oxadiazoles, Antimicrobial Activity
[01] S. Bondock, A. E. Tarhoni, A. A. Fadda // ARKIVOC2006, ix, pp. 113-156.
[02] B. Hegazi, H. Abdel-Gawad, H. A. Mohamed, F. A. Badria, A. M. Farag// J Heterocyclic Chem 2013, 50, pp. 355-360.
[03] P. Majumdar, A. Pati, M. Patra, R. K. Behera, A. K. Behera//Chem. Rev. 2014, 114, pp. 2942-2977 and references cited therein.
[04] B. Namratha, S. L. Gaonkar// Int J Pharm Pharm Sci. 2014, 6, pp. 73-80 and references cited therein.
[05] V. K. R. Sahu, A. K. Singh, D. Yadav// Int. J. ChemTech Res. 2011, 3, pp. 1362-172 and references cited therein.
[06] K. A. Kumar, P. Jayaroopa, G. V. Kumar// Int. J. ChemTech Res. 2012, 4, pp. 1782-1791 and references cited therein.
[07] V. Chandregowda, A. K. Kush, R. G. Chandrasekara//Eur J Med Chem 2009, 44, pp. 3046-3055.
[08] G. Saravanan, V. Alagarsamy, C. R. Prakash//Int J PharmSci 2010, 2, pp. 83-86.
[09] K. A. Devi, M. Sarangapani, M. Sriram// Int. J. Drug Dev. & Res. 2012, 4, pp. 324-327.
[10] E. S. Abbas, M. F. Awadallah, A. N. Ibrahim, G. E. Said, M. G. Kamel//Eur J Med Chem 2012, 53, pp. 141-149.
[11] A. S. El-Azab, S. G. Abdel-Hamide, M. M. Sayed-Ahmed, G. S. Hassan, T. M. El-Hdiyah, O. A. Al-Shabanah,, O. A. Al-Deeb, H. I. El-Subbagh// Med Chem Res 2013, 22, pp. 2815-2827.
[12] A. K. Tiwari, A. K. Mishra, A. Bajpai, P. Mishra, R. K. Sharma, V. K. Pandey, V. K. Singh//Bioorg Med Chem Lett 2006, 16, pp. 4581–4585.
[13] M. E. Azab, E. A. Kassab, M. A. El-Hashash, R. S. Ali// Phosphorus, Sulfur, Silicon and Relat Elem 2009, 184, pp. 610-625.
[14] M. A. El-Hashash, D. B. Guirguis, Y. A. El-Badry// Der Pharma Chemica. 2011, 3, pp. 147-159.
[15] M. A. El-Hashash, M. M. El-Shahawi, E. A. Ragab, S. Nagdy// Synth Commun. 2015, 45, pp. 2240-2250.
[16] M. I. Marzouk, T. A. Farghaly, M. A. El-Hashash, S. A. Shaker, S. M. Hussein//Heterocycles. 2015, 91, pp. 1399-1416.
[17] J. You, C. Ye, Y. Weng, X. Mo, Y. Wang// ARKIVOC, 2008, xvii, pp. 1-11
[18] Hector, R. F. // Clin. Microbiol. Rev. 1993, 6, pp. 1–21.
[19] Cooper, R. E. Analytical Microbiology, In Kavanageh FW, Academic press, New York and London, 1972.
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