International Journal of Life Science and Engineering
Articles Information
International Journal of Life Science and Engineering, Vol.1, No.4, Sep. 2015, Pub. Date: Jul. 15, 2015
Plasma Activity of Tartrate Resistant Acid Phosphatase in Acute Malaria Infection
Pages: 183-188 Views: 3273 Downloads: 1068
[01] Abubakar El-Ishaq, School of Science and Technology, Science Laboratory Technology Department, Biochemistry, Hemistry Unit, Federal Polytechnic Damaturu, Yobe State, Nigeria.
[02] Timothy O. Omoluabi, School of Science and Technology, Science Laboratory Technology Department, Biochemistry, Hemistry Unit, Federal Polytechnic Damaturu, Yobe State, Nigeria.
Enzymes are biological molecules that modulate rate of chemical reactions within an optimum temprature and Hydrogen potential without themselve been used up.The activity of tartrate-resistant acid phosphatase E.C . Orthophosphoric monoester phosphohydrolase was assayed using the plasma of patient presenting with acute malaria. Objective of this study is to explore an alternative enzymatic approaches for diagnosis of severe malarial parasite infection. Total plasma tartrate-resistant acid phosphatase was assayed according to procedure of (Henry and Steer, 1999).The results obtained showed mean activity of 69.09±1.56IU, 110.02±0.74IU and 125.46±0.79IU, for infected male adults, female adults, and children respectively. These were found to differ significantly (p >0.05) from that of normal adult Males, Females and Children having mean activities of 182.68±0.93IU, 162.01±0.79IU and 178.37±1.03IU respectively. The research work revealed plasma activities of tartrate-resistant acid phosphatase for infected males, females and children, this means that tartrate resistance acid Phosphatase may possibly serves as an index in diagnosis of malaria parasite infection and its severity.
Tartarate, Phosphatase, Malaria, Damaturu, Plasmodium, Marker Enzyme
[01] Ash, J.E and Spitz, S. (1976). Pathology of Tropical Diseases. W.B Sanders. Philadelphia. U.S.A. Pp. 354 – 356.
[02] Baumbach, G. A (1991) .Uteroferrin contains complex and high mannose-type oligosaccharide synthesized in vitro. molecular cell biochemistry. 105(2): PP107.
[03] Briggs, T.A, Rice, G.I, Daly, S. Urguhart, J .and Gornall, H. (2011). Tartrate- resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type interferon expression signature. nature. genetics.43,127-131.doi;10.1038/ng.748.
[04] Burstone, M. S. (1959). Histochemical demonstration of acid phosphatase activity in osteoclasts. journal of cytochemistry 7(1): Pp. 39 – 41.
[05] Calibreath, D. F. (1992). Chemical Chemistry. W.B Sanders. Philadelphia U.S.A. P. 162.
[06] David, L. Nelson and Michael, M. Cox. (2005). Principles of Biochemistry, 4th Edition, W.H. Freeman and Company New York City U.S.A. P. 613.
[07] Data, S.W. P and Ottawary, J. H. (1979). Biochemistry. 3rd edition, Cassel. London. P. 295.
[08] Darden A. G. (1996). Osteoblastic superoxide production and bone resumption: stimulation by modulator of NADPH oxidase. 11(5): Pp. 671 – 675.
[09] Federal Republic of Nigeria (2004). National Policy on Education. Lagos. NERC Press.
[10] Garba, I.H, Gatsing, D. Ubom, G . (2006). Elevated total and isoenzyme forms of acid phosphatase in falciparum malaria. C R Biol. Feb; 329(2):75-8. Epub 2006 Jan 18.
[11] Henry, Y. and Steer, M. W. (1999). Acid Phosphatase Localization in the Digestive gland. Journal of Histochemistry and Cytochemistry Pp. 339 – 344.
[12] Hayman, A. R. (2008). Tartrate-resistant acid phosphatase and the osteoclast/immune cell dichotomy. Autoimmunity. April, 2008.41(3); 218- 223.doi 10.1080/08916930701694667.
[13] Hayman, A. R. (1996).Nice lacking tartrate-resistant acid phosphatase (acp5) have disrupted endochondral ossification and mild osteopetrosis. Development 122(10): P 3151 – 3162.
[14] 10/10/2005
[15] Joan F. Z live and Pannal P. R. (1981). Clinical Chemistry in Diagnosis and Treatment 3rd edition. Lloyd-Luke. London. Pp. 343 – 346.
[16] Jon Cohen. (2014).A hard look at global health measures. Science. Volume 345. Issue 6202.pp 1260-1265.September, 2014
[17] Keith Wilson and Kenneth, H. (1986). A Biologist’s Guiding Principle and Techniques of Practical Biochemistry 3rd edition. Hodder and Stoughton, London. Pp. 182 -183.
[18] Klabunde, T. (1996). Mechanism of Fe (III) - Zn (II) purple acid phosphatase based on crystal, journal of molecular biology 259 (4): P. 737 – 748.
[19] Lansing, M. Prescott, John P. Harley, Donald Alien .(2002). Microbiology 5th Edition, McGraw-Hill Companies New York City U.S.A. Pp. 954 – 956.
[20] Lehninger, A.L. (1982). Principles of Biochemistry 2nd edition. Worth, New York City U.S.A. P. 1101.
[21] Ljusberg J, Rylander E. K. and Aderson G. (2005). Tartrate resistant purple acid phosphatase synthesized as a latent proenzyme and activated by cysteine proteases. biochemistry journal. pp. 28370 – 81.
[22] jusberg, j. (2005). Proteolytic excision of a repressive loop domains in tartrate-resistant acid phosphatase by cathepsin k. in osteoclasis. Journal of Biochemistry 280: (31): P. 28370 – 81.
[23] Minkin, C. (1982). Bone acid phosphatase as a marker of osteoclast function. 34(3): P 285 – 290.
[24] Nelson, D.L. and Cox, M.M .(2005).: Lehninger: Principles of Biochemistry, 4th Edition, W.H. Freeman and Co.
[25] Prescott, M.L. Harley, P.J. and Klein, D.A.(2002).Microbiology.5th edition. McGraw- Hill.1026pages.
[26] Rylander, E. K. (1994). Dephosphorylation of osteopontin and bone sialoprotein by the osteoclast tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion vtro. Journal of Biochemistry. P. 14853 – 14856.
[27] Sunday Punch, Volume 24, Number 994. Nigeria. (April 30, 2000) Pp. 31– 32.
[28] download 06/11/2005
[29] World Health Organization. (1998). A Journal of Annual Review of Malaria Pp. 94 – 102.
[30] Zilva, J.F. Pannal, P.R. and Mayane, P.D.(1988).Clinical Chemistry in Diagnosis and Treatment.5th edition. Loyd-Luke.London.pp.454.
MA 02210, USA
AIS is an academia-oriented and non-commercial institute aiming at providing users with a way to quickly and easily get the academic and scientific information.
Copyright © 2014 - American Institute of Science except certain content provided by third parties.