[01] Jahanara Nasrin, Department of Materials Science and Engineering, University of Rajshahi, Rajshahi, Bangladesh.

Peroxo metal complexes have an important place within the medicinal inorganic chemistry since they exhibit different oxidation states and can interact with a number of negatively charged molecules. This activity of transition metals led to the recent development to of drugs which are based on metals and are considered to be potential candidates for pharmacological and the rapeutic applications. Both the ligand and the metal complexes of Th(IV) were screened for their antibacterial activity against Pseudomonas aeruginosa, Sarcina lutea, Streptococcus bodyii, Streptococcus--haemolyticus. Escherichia coli, Bacillus megaterium, B. subtilis, Shigella sonnei, S.flexneri, S.dysenteriae, S.bodyii and S.shiga. The toxicidal activity of the ligand and its complexes against the brine shrimp was also investigated. The screening results revealed that the compound K[ThO(O₂)(ala)(4-pic)] has a strong inhibition and active antimicrobial activities against the bacteria compared to other compound tested. Results also showed that the lethal toxicity of peroxo complexes of metal Th(IV) varied significantly against the mortality of brine shrimp at different exposure periods. The complex K[ThO(O₂)(gly)(2-pic)] was found to be more toxic against the mortality brine shrimp indicating the lower values of 8.49 and 203.8g/mL lethal concentration for 50 (LC₉₉) and 99% (LC₉₉) respectively at both exposures of 36-h.

Peroxo Complexes, Bactericidal Activity, Cytotoxicity, Lethal Toxicity, Microbial Activity

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