[01] Sachin Jain, College of Pharmacy, IPS Academy, Indore, India. [02] G. P. Choudhary, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, India. [03] D. K. Jain, College of Pharmacy, IPS Academy, Indore, India.

Jatropha gossypifolia Linn. (JG) has been traditionally used in the Ayurvedic system of medicine as a chief ingredient of many polyherbal formulations as antioxidant. To evaluate the antioxidant and hepatoprotective activity of ethanolic extract of Jatropha gossypifolia leaves. Animals were pre-treated with ethanolic plant extract for 7 days and then toxicity was induced with a single CCl4 intraperitoneal injection. Pre-treatment with 500 mg/kg (p.o.) of ethanolic extract of Jatropha gossypifolia improved the glutathione (oxidized), SOD, catalase, and peroxidase lipid peroxidation levels significantly as compared to control group. Liv 52 was used as standard reference and exhibited significant hepatoprotective activity against carbon tetrachloride induced hepatotoxicity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections. The results of this study strongly indicate that Jatropha gossypifolia leaves have potent hepatoprotective action against carbon tetrachloride induced hepatic damage in rats. Ethanolic extract was found more potent hepatoprotective. Meanwhile, in vivo antioxidant activities were also screened which were positive for ethanolic extracts. On the basis of this study we conclude that ethanolic extract of Jatropha gossypifolia possesses in vivo antioxidant activity and can be employed in protecting tissue from oxidative damage and stress.

Jatropha gossypifolia, Liv 52, CCl4, Antioxidant Activity, Superoxide Dismutase, Hepatoprotective

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