[01] Sameer Shah, Department of Biotechnology, CMR Institute of Management Studies (Autonomous), Bangalore, Karnataka, India. [02] Mani Ramakrishnan, Department of Biotechnology, CMR Institute of Management Studies (Autonomous), Bangalore, Karnataka, India. [03] Ramesh Puttalingaiah Thylur, Drug Discovery Research Lab, Skanda Life Sciences Pvt. Ltd., Sunkadakatte, Bangalore, Karnataka, India. [04] Yogisha Shivanna, Drug Discovery Research Lab, Skanda Life Sciences Pvt. Ltd., Sunkadakatte, Bangalore, Karnataka, India.

Plants are important source for screening and development of herbal medicines, herbs have been on the forefront whenever we talk about cancer cure and herbal medicines have a vital role in the prevention and treatment of cancer. In the present investigation, an attempt was made to exploit bioactive compounds of three medicinal plants viz. Curcuma longa L., Clitoria ternatea L. and Aloe vera (L.) Burm. f., investigated their anti-proliferative properties in-vitro on lung carcinoma and evaluated the haemolytic activity. Methanolic extract of Curcuma longa L. showed inhibition (IC 50=207.3 µg/ml) of growth against human lung carcinoma cell line (A549) and inhibition was not observed for Clitoria ternatea L. and aqueous extract of Aloe vera (L.) Burm.f. while all three plants found to be non haemolytic. Our studies infer that the bioactive compounds of Curcuma longa L. are a potent medicinal source for human lung cancer as it showed a significant inhibition of growth of cancer cells and non haemolytic in nature.

Curcuma longa L., Anti-Proliferative, In-Vitro Cytotoxicity, Haemolytic Activity, Human Lung Carcinoma, A549

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