International Journal of Plant Science and Ecology
Articles Information
International Journal of Plant Science and Ecology, Vol.1, No.3, Jun. 2015, Pub. Date: Apr. 20, 2015
The Effect of Daucus carota Seeds Extract on Lipid Profile, LFT and Kidney Function Indicators in Streptozocin-Induced Diabetic Rats
Pages: 84-87 Views: 4238 Downloads: 2520
Authors
[01] Iran Pouraboli, Department of Biology, School of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
[02] Banafshe Ranjbar, Department of Biology, School of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
Abstract
Daucus carota ssp. sativum (Apiaceae) seeds include antioxidant agents, which can improve diabetes mellitus complications. This study was designed to investigate the effect of the methanol extract of D. carota (wild carrot) seeds on the serum levels of lipids and biochemical indices of kidney and liver function in streptozocin-induced diabetic rats. Diabetes mellitus (type I) was induced using intraperitoneal injection of streptozotocin (65 mg/kg). Fasting blood samples were collected one week later and rats with their serum glucose level exceeding 300 mg/dl were considered diabetics. These diabetic animals were divided into 5 groups and received various doses of D. carota seeds extract (100, 200 and 300 mg/kg body wt.), glibenclamide (600 μg/kg) and distilled water (0.5 ml) for 6 days using gavage. After tratment, fasting blood samples were collected again and total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase (AST), alanine aminotransferase (ALT), high density lipoprotein cholesterol (HDL-C) and Low density lipoprotein cholesterol (LDL-C) levels were determined using spectrophotometry technique by respective kits. Administration of D. carota seeds extract in diabetic rats for six days, at all doses significantly decreased serum levels of total cholesterol, triglycerides and creatinine. Furthermore, oral administration of extract (200 and 300 mg/kg) significantly decreased serum levels of LDL-C, AST and urea. Also, extract (300 mg/kg) decreased ALT serum levels (P < 0.05). Thus D. carota seeds extract exerted antihyperlipidemic properties with no adverse effect on liver and kidney function.
Keywords
Daucus carota Seeds, Diabetes Mellitus, Lipids, Kidney, Liver Enzymes
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