[01] Shruti Bandopadhyaya, PG Department of Biotechnology, CMR Institute of Management Studies (Autonomous), # 5, 2nd Cross, 4th Main OMBR Layout, Bangalore, Karnataka, India;Stem Cell Biology Laboratory, L V Prasad Eye Institute, Hyderabad, India. [02] Mani Ramakrishnan, PG Department of Biotechnology, CMR Institute of Management Studies (Autonomous), # 5, 2nd Cross, 4th Main OMBR Layout, Bangalore, Karnataka, India. [03] Ramesh Puttalingaiah Thylur, Drug Discovery Research Lab, Skanda Life Sciences Pvt. Ltd., Sunkadakatte, Bangalore, Karnataka, India. [04] Yogisha Shivanna, Drug Discovery Research Lab, Skanda Life Sciences Pvt. Ltd., Sunkadakatte, Bangalore, Karnataka, India.

Mammalian tumour cells exhibit resistance to chemotherapy and its severe side effects reduces the clinical efficacy of a large variety of anticancer agents. Plant-derived compounds manifest many beneficial effects and can possibly inhibit several stages of cancer. Despite there is significant progress in cancer therapeutics in the last decades, the need to discover, develop new and synergistic plant based anticancer agents are in the emerging stage. In the present study, we attempted to exploit bioactive compounds of three plants viz. Cinnamomum camphora, Catharanthus roseus and Emblica officinalis, investigated their anti-proliferative properties for colon cancer and evaluated the haemolytic activity. Methanol extracts of these plants were subjected to cytotoxic assay and found that C. roseus and E. officinalis selectively inhibited hct 116 cell proliferation and all the three plants are non-haemolytic. Our findings infer that the potential bioactive compounds of these plants have vibrant chance to fight colon cancer as were seen to be non-haemolytic to blood cells and they are well documented as a traditional medicine for therapeutic uses.

Cinnamomum camphora, C. roseus and Emblica officinalis, HCT 116 Cell Line, Cytotoxic Assay, Alkaloids, Anti-Proliferative Activity, Haemolytic Activity

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