Journal of Biological and Environmental Engineering
Articles Information
Journal of Biological and Environmental Engineering, Vol.2, No.1, Jan. 2017, Pub. Date: Jul. 27, 2017
Association Mapping, Principles and Techniques
Pages: 1-9 Views: 2083 Downloads: 1476
Authors
[01] Ujjawal Kumar Singh Kushwaha, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[02] Vikas Mangal, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[03] Anil Kumar Bairwa, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[04] Sneha Adhikari, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[05] Tabassum Ahmed, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[06] Pallavi Bhat, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[07] Ankit Yadav, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[08] Narendra Dhaka, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[09] Deepak Raj Prajapati, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[10] Amit Kumar Gaur, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[11] Ranjana Tamta, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[12] Indra Deo, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
[13] Narendra Kumar Singh, Department of Genetics and Plant Breeding, College of Agriculture, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttrakhand, India.
Abstract
Association mapping is a powerful tool for the dissection of complex agronomic traits and for the identification of alleles. It is a very efficient and effective method for confirming candidate genes or for identifying new genes. Association mapping is a useful alternative to standard QTL mapping approaches which involves the correlation of molecular polymorphisms with phenotypic variation in a diverse assemblage of individuals. The comparatively high-resolution provided by association mapping is based on the structure of linkage disequilibrium (LD) across the genome. Many factors adversly affects association mapping, including population structure, small sample size, and low frequency of specific alleles that may increase the detection of a false positive associations. Association mapping offers great potential to enhance crop genetic improvement. Still extensive research is needed to understand the expansive application of association mapping. This review describes association mapping in detail along with its principles, techniques and application.
Keywords
Association Mapping, Linkage Disequilibrium, Population Size, Crop Improvement, Alleles
References
[01] Altshuler, D., M.J. Daly, and E.S. Lander. 2008. Genetic mapping in human disease. Science 322(5903):881–888.
[02] Balasubramanian, S. et al. 2009. QTL mapping in new Arabidopsis thaliana advanced intercross-recombinant inbred lines. PLoS ONE4, e4318.
[03] Breseghello, F. and M.S. Sorrells (2006) Association mapping of kernel size and milling quality in wheat (TriticumaestivumL.) cultivars. Genetics 172:1165-1177.
[04] Brotman, Y. et al. 2011. Identification of enzymatic and regulatory genes of plant metabolism through QTL analysis inArabidopsis. J. Plant Physiol. 168, 1387–1394.
[05] Buckler, E.S. and JM Thornsberry 2002. Plant molecular diversity and applications to genomics. CurrOpin Plant Biol 5: 107–111.
[06] Cardon, L.R., and J.I. Bell 2001. Association study designs for com-plex diseases. Nat Rev Genet 2:91-99.
[07] Chan, E.K.F. et al. 2011. Combining genome-wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana. PLoS Biol.9, e1001125.
[08] Chan, E.K.F. et al. 2010. Understanding the evolution of defense metabolites inArabidopsisthalianausing genome-wide association mapping.Genetics185, 991–1007
[09] Ching A., K.S., Caldwell, M. Jung, M. Dolan, O.S. Smith, S. Tingey, M. Morgante, A.J., Rafalski 2001. SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines.BMC Genet, 3:19.
[10] Devlin, B., and K. Roeder. 1999. Genomic control for association studies. Biometrics 55:997–1004.
[11] Dobon, A. et al. 2011. Quantitative genetic analysis of salicylic acid perception inArabidopsis. Planta234, 671–684.
[12] Doerge, R.W. 2002. Mapping and analysis of quantitative trait loci in experimental populations. Nat. Rev. Genet. 3:43–52.
[13] Dooner, H.K., and L. He 2008. Maize genome structure variation: Inter-play between retrotransposon polymorphisms and genic recombina-tion. Plant Cell 20:249–258.
[14] Ehrenreich I.M., Stafford P.A. and Purugganan M.D. 2007. The ge-netic architecture of shoot branching in Arabidopsis thaliana: A comparative assessment of candidate gene asso-ciations vs. quantitative trait locus mapping. Genetics 176:1223-1236.
[15] Ersoz, E.S., J. Yu, and E.S. Buckler, IV. 2009. Applications of linkage dis-equilibrium and association mapping in maize. p. 173–195. InA. L. Kriz and B. A. Larkins (ed.) Molecular genetic approaches to maizeimprovement. Springer-Verlag, New York, NY.
[16] Flint-Garcia S. A., J. M. Thornsberry, ES Buckler 2003. Structure of linkage disequilibrium in plants. Annu Rev Plant Biol,54:357-374.
[17] Flint-Garcia, S. A., A. C. Thuillet, J. Yu, G. Pressoir, S. M. Romero, S. E. Mitchell, J. Doebley, S. Kresovich, M. M. Goodman, and E. S. Buckler. 2005. Maize association population: A high-resolution platform for quantitative trait locus dissection. Plant J. 44:1054–1064.
[18] Flint-Garcia, S.A., J.M. Thornsberry, and E.S. Buckler. 2003. Structure of linkage disequilibrium in plants. Annu. Rev. Plant Biol. 54:357–374.
[19] Garris, A.J., S.R.Mc Couch and S. Kresovich. 2003. Population structure and its effects on haplotype diversity and linkage disequilibrium surrounding the xa5 locus of rice OryzasativaL. Genetics 165:759-769.
[20] Glazier A.M., Nadeau J.H. and T.J.Aitman. 2002. Finding genes that underlie complex traits. Science 298:2345-2349. .
[21] Gordon, D., and S.J. Finch. 2005. Factors affecting statistical power in thedetection of genetic association. J. Clin. Invest. 115:1408–1418.
[22] Hackett, C.A. 2002. Statistical methods of QTL mapping in cere-als. Plant MolBiol 48:585-599.
[23] Hamblin, M.T., Mitchell, S.E., White G.M., Gallego J., Kukatla R., Wing R.A., Paterson A.H. and S. Kresovich 2004. Comparative population genetics of the panicoid grasses: Sequence polymorphism, linkage disequilibrium and selection in a di-verse sample ofSorghum bicolor. Genetics 167:471-483.
[24] Hedrick, P.W. 1987.Gametic disequilibrium measures: Proceed with cau-tion. Genetics 117:331–341.
[25] Hunter, K.W., and N.P. Crawford. 2008. The future of mouse QTL map-ping to diagnose disease in mice in the age of whole-genome associa-tion studies. Annu. Rev. Genet. 42:131–141.
[26] Hyten, D.L., Choi I.Y., Song Q., Shoemaker R.C., Nelson R.L., Costa J.M., Specht J.E. and Cregan P.B. 2007. Highly variable pat-terns of linkage disequilibrium in multiple soybean popula-tions. Genetics 175:1937-1944.
[27] Kraakman, A.T.W., Martínez F., Mussiraliev B., van Eeuwijk F.A. and Niks R.E. 2006. Linkage disequilibrium mapping of mor-phological, resistance, and other agronomically relevant traits in modern spring barley cultivars. Mol Breed 17:41-58.
[28] Kraakman, A.T.W., R.E. Niks, Van der Berg P.M.M.M., Stam P. and F.A. Van Eeuwijk. 2004. Linkage disequilibrium mapping of yield and yield stability in modern spring barley cultivars. Genetics 168:435-46.
[29] Mackay, T.F. 2001. The genetic architecture of quantitative traits. Annu Rev Genet 35:303-339.
[30] Mackay, I., and W. Powell. 2007. Methods for linkage disequilibrium map-ping in crops. Trends Plant Sci. 12:57–63.
[31] Malysheva-Otto L. and Röder M.S. 2006. Haplotype diversity in the endosperm specificβ-amylase geneβmy1 of cultivated barley (HordeumvulgareL.). Mol Breed 18:143-156.
[32] Oraguzie, N.C., Rikkerink E.H.A., Gardiner S.E. and Silva H.N. de 2007. Association Mapping in Plants. Springer, Tokio and New York, 277 pp.
[33] Palaisa, K.A., M. Morgante, M. Williams, A. Rafalski 2003. Contrasting effects of selection on sequence diversity and linkage disequilibrium at two phytoene synthase loci. Plant Cell,15:1795-1806.
[34] Patterson, N., A.L. Price, and D. Reich. 2006. Population structure and eigenanalysis. PLoS Genet. 2:e190.
[35] Price, A.L., N.J. Patterson, R.M. Plenge, M.E. Weinblatt, N.A. Shadick, et al. 2006. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904–909. doi:10.1038/ng1847.
[36] Pritchard, J.K. and N.A. Rosenberg 1999. Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 65:220-28.
[37] Pritchard, J.K., M. Stephens, N.A. Rosenberg and P. Donnelly 2000. Association mapping in structured populations. Am J Hum Genet 37:170-181.
[38] Pritchard, J., M. Stephens, N.Rosenberg and P. Donnelly. 2000. Association mapping in structured populations. Am. J. Hum. Genet.67:170–181.
[39] Rafalski, J.A. 2010 Association genetics in crop improvement. Curr. Opin. Plant Biol. 13:174–180.
[40] Ravel C., Praud S., Murigneux A., Linossier L., Dardevet M., Balfourier F., Dufour P.H., Brunel D. and G. Charmet.2006. Identification of Glu-B1-1as a candidate gene for the quan-tity of high-molecular-weight glutenin in bread wheat (TriticumaestivumL.) by means of an association study, TheorAppl Genet 112:738-743.
[41] Remington, D.L., Thornsberry, J.M., Matsuoka Y., Wilson L.M., Whitt S.R., Doebley J., Kresovich S., Goodman M.M. and Buckler E.S. IV 2001. Structure of linkage disequilibrium and pheno-typic associations in the maize genome. Proc Nat AcadSci USA 98:11479-11484.
[42] Rosenberg, N.A., Pritchard J.K., Weber J.L., Cann H.M., Kidd K.K., Zhivotovsky L.A. and Feldman M.W. 2002. Genetic structure of human populations. Science 298:2381-2385.
[43] Rostoks, N., Ramsay L., MacKenzie K., Cardle L., Bhat P.R., Roose M.L., Svensson J.T., Stein N., Varshney R.K., D.F. Marshall, et al. 2006. Recent history of artificial outcrossing facilitates whole-genome association mapping in elite inbred crop va-rieties. ProcNatlAcadSci USA 103:18656-18661.
[44] Singh, B.D., A.K. Singh. 2016. Marker assisted plant breeding: principles and practices, Springer
[45] Tenaillon, M.I., M.C. Sawkins, A.D. Long, R.L. Gaut, J.F. Doebley, B.S. Gaut 2001. Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea maysspL.). ProcNatlAcadSci USA,98:9161-9166.
[46] Thornsberry, J.M., Goodman, M.M., Doebley, J., Kresovich, S., Nielsen, D. and Buckler E.S. IV 2001. Dwarf8 polymorphisms associ-ate with variation in flowering time. Nat Genet 28:286-289.
[47] Tommasini, L., Schnurbusch T., Fossati D., Mascher F. and Keller B. 2007. Association mapping of Stagonosporanodorum blotch resistance in modern European winter wheat varieties. TheorAppl Genet 115:697-708.
[48] Visscher, P.M. 2008. Sizing up human height variation. Nat. Genet. 40:489–490.
[49] Xing Y., Frei U., Schejbel B., Asp T. and T. Lübberstedt. 2007. Nucleotide diversity and linkage disequilibrium in 11 expres-sed resistance candidate genes in Loliumperenne. BMC Plant Biol 7:43.
[50] Yan, J.B., T. Shah, M.L. Warburton, E.S. Buckler, M.D. McMullen, and J. Crouch. 2009. Genetic characterization and linkage dis-equilibrium estimation of a global maize collection using SNP markers. PLoS One 4:e8451.
[51] Yan, Jianbing Marilyn Warburton, and Jonathan Crouch. 2011. Association Mapping for Enhancing Maize (Zeamays L.) Genetic Improvement. Crop Sci. 51:433–449.
[52] Yu Jianming and Edward S Buckler 2006. Genetic association mapping and genome organization of maizeCurrent Opinion in Biotechnology 2006, 17:155–160.
[53] Zhu, C., and J. Yu. 2009. Nonmetric multidimensional scaling cor-rects for population structure in association mapping with differ-ent sample types. Genetics 182:875–888.
[54] Zhu, C., M. Gore, E.S. Buckler, and J. Yu. 2008. Status and prospects of association mapping in plants. Plant Gen. 1:5–20.
[55] Zhu, C. et al. 2008. Status and prospects of association mapping in plants.Plant Gen.1, 5–20.
600 ATLANTIC AVE, BOSTON,
MA 02210, USA
+001-6179630233
AIS is an academia-oriented and non-commercial institute aiming at providing users with a way to quickly and easily get the academic and scientific information.
Copyright © 2014 - American Institute of Science except certain content provided by third parties.